HEMATOPOIETIC GROWTH-FACTORS AND DOSE INTENSITY IN HIGH-GRADE AND INTERMEDIATE-GRADE LYMPHOMA

Authors
PETTENGELL R CROWTHER D
Citation
R. Pettengell et D. Crowther, HEMATOPOIETIC GROWTH-FACTORS AND DOSE INTENSITY IN HIGH-GRADE AND INTERMEDIATE-GRADE LYMPHOMA, Annals of oncology, 5, 1994, pp. 190000133-190000141
Citations number
70
Categorie Soggetti
Oncology
Journal title
Annals of oncology → ACNP
ISSN journal
09237534
Volume
5
Year of publication
1994
Supplement
2
Pages
190000133 - 190000141
Database
ISI
SICI code
0923-7534(1994)5:<190000133:HGADII>2.0.ZU;2-S
Abstract
Here we review the evidence that cytotoxic dose intensity is an import ant determinant of outcome in high- and intermediate-grade non-Hodgkin 's lymphoma. The results of retrospective analyses and prospective stu dies support this proposition but confirmatory studies are required. W e discuss the role of haemopoietic growth factors and mobilized periph eral blood progenitor cells to increase dose intensity. Studies using these modalities will enable the importance of dose intensity to be te sted.