Weight loss, chronic diarrhea and fat malabsorption are frequent after
total gastrectomy. The aim of this work was to stuyd parameter's of i
ntestinal absorption and the histology of jejunal mucosa in 26 patient
s subjected, at least one year ago, to total gastrectomy and without e
vidences of tumoral relapse. There was a mean weight loss of 9 kg (ran
ge 4 to 20) and 46% of patients had intermittent or episodical diarrhe
a. Hemoglobin was below 12 g/dl in 4 patients, serum albumin was below
3.5 g/dl in 3, serum carotene was below 40 ug/dl in 5 and serum iron
was below 80 ug/dl in 5. Jejunal biopsies were normal and steatocrit w
as abnormal in all patients. Present findings suggest that fat malabso
rption in these patients is intraluminal and due to an unequal mix of
pancreatic and biliary secretions, as a consequence of Y en Roux trans
it reconstruction.