INDUCED SALMONELLA-CHOLERAESUIS INFECTION IN PIGS - THE EFFECT OF AUREO-SP-250 VS NO DRUG ON CLINICAL-DISEASE, DURATION OF SHEDDING, AND TISSUE LOCALIZATION

Twelve pens of five 30-lb pigs each were offered diets containing eith er Aureo SP-250 (ASP-250:American Cyanamid, Princeton, N.J.) or no med ication. All pigs were inoculated intragastrically with virulent Salmo nella choleraesuis. Pigs which received Aureo SP-250 had less death lo ss, less severe clinical illness, gained significantly more weight, an d had significantly improved feed efficiency. S. choleraesuis isolatio n attempts from pharyngeal tonsils and feces indicated a higher preval ence and a longer duration of shedding in non-medicated pigs when comp ared to medicated pigs. At necropsy, S. choleraesuis was detectable in fewer tissues and from fewer pigs receiving oral medication.