We assessed the relation of serum iron, dietary iron, and the use of i
ron supplements to the risk of fatal acute myocardial infarction in th
e Nutrition Canada Survey cohort. We found an association between seru
m iron and risk of fatal acute myocardial infarction, with rare ratios
for males and females in the highest category of serum iron (greater
than or equal to 175 mu g per dl):of 2.18 [95% confidence intervals (C
I) = 1.01-4.74] and 5.53 (95% CI = 1.69-18.12), respectively. We found
no important association between risk of fatal acute myocardial infar
ction and either dietary iron or iron supplement use among the 9,920 p
articipants included in this study.