H. Klemfuss et Df. Kripke, POTASSIUM, RUBIDIUM, AND 4-AMINOPYRIDINE EFFECTS ON THE CIRCADIAN RUNNING RHYTHM IN THE HAMSTER, Pharmacology, biochemistry and behavior, 47(3), 1994, pp. 409-412
The period of the circadian rhythm of wheel-running was shortened when
golden hamsters were given supplemental dietary potassium or rubidium
for two weeks. Treatment with 4-aminopyridine, a potassium channel bl
ocker, significantly increased circadian period. These period changes
(0.17 h for potassium treatment, 0.14 h for rubidium, and 0.07 h for 4
-aminopyridine) support previous data indicating that potassium is a c
omponent of the mammalian biological clock mechanism.