ANALGESIC AND ANTIINFLAMMATORY EFFECTS OF SOME NEW 6-ACYL-3-SUBSTITUTED-2(3H)-BENZOXAZOLONE DERIVATIVES

6-Acyl-2(3H)-benzoxazolone derivatives were reacted with 4-substituted phenacyl bromide in ethanol to give the corresponding 4-substitutedbe nzoyl)methyl]-2(3H)-benzoxazolones. The compounds were screened for th eir analgesic, antiinflammatory activities. The eight compounds synthe sized showed high analgesic activities and further Investigation revea led compounds 3, 6 and 7 to be potent inhibitors of carrageenan- and a rachidonic acid-induced paw edema. The PGE(2) isolated from the carrag eenan paw edema fluid was also significantly low in mice treated with compounds 3, 6 and 7.