I. Ahlers et al., SUSPENSION HYPOKINESIA IN RATS - EFFECTS OF THE TIME OF DAY ON METABOLIC AND HORMONAL CHANGES, Physiological Research, 42(6), 1993, pp. 397-402
Suspension hypokinesia is a new model which can simulate some effects
of microgravity on the organism of laboratory animals. Two groups of m
ale SPF-bred Wistar rats were suspended for 24 h. In the first group h
ypokinesia began in the morning (M) (1 h after light onset, 0800 h), w
hereas the other group was subjected to this treatment from the evenin
g (E) (1 h after dark onset, 2000 h). In the serum, there was a statis
tically significant increase In non-esterified fatty acids, triacylgly
cerols (TG) and glucose and a decrease in triiodothyronine concentrati
on in the M group, while only a significant increase in phospholipids
(PL) was found in the E group. The serum corticosterone level was incr
eased in both groups, more markedly in the M group. There was an Incre
ase in TG and PL in the liver in M rats. In the bone marrow (femur), a
n increase of triglycerols in E rats and an increase of phospholipids
in M rats were found. The concentration of glycogen in the heart muscl
e, m. quadriceps femoris and m. soleus rose in the M group only. The c
hanges in the analyzed parameters predominate in the rats subjected to
hypokinesia in the morning period. This fact confirmed the hypothesis
about a higher sensitivity of rats to the stressor acting in the peri
od of inactivity.