A. Nagyova et al., HEPATIC MONOOXYGENASES AND CONJUGATING ENZYMES IN CADMIUM-INTOXICATEDHAMSTERS - EFFECT OF VITAMIN-C SUPPLEMENTATION, Physiological Research, 42(6), 1993, pp. 409-414
The effects of cadmium and simultaneous administration of cadmium and
vitamin C on hepatic microsomal monooxygenase activities, conjugation
enzyme activities and enzyme activities in the serum were investigated
in hamsters. Cadmium, as cadmium chloride, was administered to hamste
rs in a subtoxic dose in drinking water (10 mg Cd per liter) for 10 we
eks. The majority of hepatic microsomal monooxygenases and enzyme acti
vities in the serum reflecting liver damage were not significantly aff
ected by subchronic cadmium treatment. On the other hand, cytosolic gl
utathione S-transferase and serum alanine aminotransferase were signif
icantly changed by cadmium and these changes were effectively eliminat
ed by the simultaneous administration of vitamin C (1 g per liter of d
rinking water). The results indicate that long-term supplementation wi
th vitamin C may be effective in the protection of hepatic enzymes aga
inst cadmium toxicity.