The notion of the 'core set' usually refers to that group of scientist
s involved in the eventual resolution of a given technical controversy
. Drawing upon actor-network theory, we suggest that such core sets, e
specially at science/public interfaces, are, in fact, constituted from
generalized agonistic sets which entail 'non-technical' issues - poli
tical, ethical, economic. Interview material with scientists who use a
nimals in their research showed how they attempted to demarcate such a
core set with their public critics. We consider how they constricted
the core set by discursively demarcating the criteria for membership.
These included 'rationality' and 'emotional authenticity'. Elaborating
an Collins' use of 'core set', we suggest that these discourses indic
ate that scientists are potentially engaged in actively constituting a
core set by setting out cultural criteria for membership. Contrary to
the focus of actor-network theory upon 'definitive' enrolment, we fou
nd that scientists can also engage in characterizing suitable antagoni
sts. As a supplement to both core set and enrolment, we suggest the co
ncept of 'envelopment'.