EVALUATION OF DEOXYRIBONUCLEIC-ACID PLOIDY AND S-PHASE FRACTION AS PROGNOSTIC PARAMETERS IN ADVANCED EPITHELIAL OVARIAN-CARCINOMA - A PROSPECTIVE-STUDY

OBJECTIVE: Our goal was to study the prognostic value of deoxyribonucl eic acid ploidy and S-phase fraction in advanced ovarian carcinoma. ST UDY DESIGN: Prognostic factors for corrected survival were evaluated i n a prospective study including 169 patients with stage III and IV ova rian cancer treated between 1985 and 1990. RESULTS: A total of 79% of the tumors were deoxyribonucleic acid aneuploid. Deoxyribonucleic acid aneuploidy was associated with grade of differentiation. S-phase frac tion could be calculated in all deoxyribonucleic acid euploid tumors a nd 76% of the deoxyribonucleic acid aneuploid tumors. By multivariate analysis deoxyribonucleic acid ploidy, histologic type and grade, age, International Federation of Gynecology and Obstetrics stage, and amou nt of residual tumor were independent prognostic variables for correct ed survival. On the basis of Cox regression a relative risk for the in dividual patient could be calculated.CONCLUSION: Deoxyribonucleic acid ploidy gives additive prognostic information and is a useful paramete r for dividing patients with advanced ovarian cancer into risk groups for treatment decisions.