Ma. Limouzinlamothe et al., QUALITY-OF-LIFE AFTER THE MENOPAUSE - INFLUENCE OF HORMONAL REPLACEMENT THERAPY, American journal of obstetrics and gynecology, 170(2), 1994, pp. 618-624
OBJECTIVE: Our purpose was to demonstrate the clinical efficacy and ef
fect of hormone replacement therapy in menopause on quality of life. S
TUDY DESIGN: A randomized, open, and month comparison of hormone repla
cement therapy (estradiol transdermal system [Estraderm TTS] plus chlo
rmadinone) and symptomatic treatment (verapipride) was performed. Anal
ysis was by intention to treat. RESULTS: In 499 postmenopausal women w
ith moderate and severe symptoms enrolled by 101 physicians, hormone r
eplacement therapy was superior to symptomatic treatment on all assess
ments of quality of life and clinical efficacy. The effects were indep
endent of the incidence of hot flushes. CONCLUSION: The effect of horm
one replacement therapy on the quality of life of postmenopausal women
was significantly superior to symptomatic treatment.