A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY ON THE EFFECT OFCONJUGATED ESTROGENS ON SKIN THICKNESS

OBJECTIVE: Our purpose was to assess the potential benefit of therapy with conjugated estrogens therapy on skin thickness in postmenopausal women. STUDY DESIGN: Sixty postmenopausal women were randomly allocate d to receive conjugated estrogens or placebo treatment for 12 months. Neither participants nor investigators were aware of the group allocat ion. Skin thickness was measured by ultrasonography at baseline and af ter 6 to 12 months of treatment. Histologic changes were evaluated by skin biopsy at baseline and after 12 months' treatment. Quality of lif e and adverse events were recorded at each visit and at the end of tre atment. RESULTS: Treatment with conjugated estrogens for 12 months sig nificantly increases, at the level of the right great trochanter, the thickness of the skin (p < 0.01), as assessed by ultrasonography, and of the dermis (p < 0.05), as assessed by skin biopsy. No statistically significant difference was observed in the control population. Qualit y of life was reported to be improved (p < 0.05) in women treated with estrogen compared with those in the placebo group. CONCLUSION: The re sults may help postmenopausal women to better appraise the benefits of estrogen replacement therapy, and they provide further evidence of th e potential of conjugated estrogens in preventing skin aging.