The ante mortem detection of pancreatitis in four cats is reported. Cl
inical findings included vomiting, lethargy and constipation in all th
e cats, diabetes mellitus in two cats and severe jaundice and a vitami
n K responsive coagulopathy in one cat. Serum amylase was normal in al
l the cats and serum lipase was elevated in one azotaemic cat. Ultraso
nography revealed predominantly hypoechoic masses in the right cranial
quandrant of the abdomen of each cat. The anatomical location of thes
e masses was consistent with the pancreas. Gross examination supported
these ultrasonographic observations. The pancreatic lesions were char
acterised histologically as acute necrotising pancreatitis, acute necr
otising pancreatitis with abscessation, chronic active pancreatitis wi
th cystic dilatation of the pancreatic duct causing bile duct obstruct
ion and chronic active pancreatitis with nodular hyperplasia. This rep
ort indicates that pancreatitis is a clinically significant disease in
cats that may be diagnosed ante mortem.