CEREBRAL-CORTEX BETA-ADRENOCEPTOR BINDING IN BIPOLAR AFFECTIVE-DISORDER

Beta-adrenoceptor density was measured in cerebral cortex membranes ob tained postmortem from age-matched controls and subjects with bipolar disorder (BD). [I-125]Iodopindolol (PIN) binding performed using a sin gle point concentration was not different in frontal, occipital or tem poral cortex in BD. Scatchard analysis of [I-125]PIN binding in tempor al cortex confirmed the lack of differences in binding density and no changes in K(D) between these two subject groups. These findings do no t support alterations in the density or affinity of beta-adrenoceptor binding in cerebral cortex in BD.