T. Ried et al., MAPPING OF MULTIPLE DNA GAINS AND LOSSES IN PRIMARY SMALL-CELL LUNG CARCINOMAS BY COMPARATIVE GENOMIC HYBRIDIZATION, Cancer research, 54(7), 1994, pp. 1801-1806
Comparative genomic hybridization was applied for a comprehensive scre
ening of under- and overrepresentation of genetic material in 13 autop
tic small cell lung cancer specimens. The most abundant genetic change
s include DNA losses of chromosome arms 3p, 5q, 10q, 13q, and 17p and
DNA gains of 3q, 5p, 8q, and 17q. Amplification sites in these tumors
were mapped to 22 chromosome bands. The most frequently involved band
was 19q13.1 (4 cases). Bands 1p32, 2p23, 7q11.2, 8q24, and 13q33-34 we
re involved in two cases each.