GROWTH-FACTOR RECEPTOR CHANGES IN EPITHEL IAL NEOPLASTIC PROCESSES

Significant outbreaks have recently occured in understanding the under lying mechanisms of cellular malignant transformation. The aim of this article is to review, based on current literature, the dynamics of ce llular transformation and to show that those steps toward malignancy a re not random. The first part is a description of growth factor recept ors and their signaling pathways. The second part deals with anomalies in these structures and with a short review of the present knowledge in veterinary medicine.