ROLE OF REGULATORY PEPTIDE IN PATHOGENESIS OF SHOCK

The present study evaluated the pathogenetic roles of three kinds of r egulatory peptide. The results showed that (i) plasma endothelin(ET) l evel elevated significantly in septic shock rats, persistent intraveno us drip of low doses ET caused development of shock state in normal ra ts and the irreversible outcome of light hemorrhagic shock. Furthermor e, i.v. administration of specific ET-antiserum was significantly effe ctive to septic shock rats. (ii) Plasma calcitonin gene-related peptid e (CGRP) increased by 260% in septic shock rats, i.v. drip of low dose s CGRP both in early and late sepsis were effective to shock rats. (ii i) Angiotensin-II (ANG-II) contents of heart and aorta increased drama tically both in early and late septic shack, and inhibiting its increa se with Captopril in late sepsis significantly improved the shock stat e, but results were inverse in early sepsis. It could be concluded tha t ET was one of the most important factors participating in the pathog enesis of shock, CGRP had a compensatory regulatory role in shock and the role of tissue ANG-II was different during different periods of sh ock.