SR-48692 INHIBITS NEUROTENSIN-INDUCED [H-3] DOPAMINE RELEASE IN RAT STRIATAL SLICES AND MESENCEPHALIC CULTURES

Authors
BROUARD A HEAULME M LEYRIS R PELAPRAT D GULLY D KITABGI P LEFUR G ROSTENE W
Citation
A. Brouard et al., SR-48692 INHIBITS NEUROTENSIN-INDUCED [H-3] DOPAMINE RELEASE IN RAT STRIATAL SLICES AND MESENCEPHALIC CULTURES, European journal of pharmacology, 253(3), 1994, pp. 289-291
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
253
Issue
3
Year of publication
1994
Pages
289 - 291
Database
ISI
SICI code
0014-2999(1994)253:3<289:SIN[DR>2.0.ZU;2-S
Abstract
In rat striatal slices, the increase (114 +/- 11%) in K+-evoked [H-3]d opamine release induced by neurotensin (10 nM) was antagonized by xyla mino]tricyclo(3.3.1.1.(3.7))decan-2-carboxylic acid (SR 48692, IC50 = 1.2 +/- 0.11 nM). SR 48692 (100 nM) also suppressed the neurotensin (1 0 nM)-induced increase (47%) in K+-evoked [H-3]dopamine release in pri mary cultures of fetal rat mesencephalic cells. These results further characterize SR 48692 as a potent antagonist of neurotensin receptors in the rat.