Vj. Blazis et al., SYNTHESIS OF SOME IDEOXY-ALPHA,BETA-L-GLYCERO-TETRURONO-1,4-LACTONES - EVALUATION AS ANTITUMOR AGENTS, Carbohydrate research, 253, 1994, pp. 225-233
A series of -dideoxy-5-O-trityl-D-erythro-pentono-1,4-lactones were de
tritylated. The resultant free-hydroxy compounds Were converted to the
ir respective ideoxy-alpha,beta-L-glycero-tetrurono-1,4-lactones (L-su
gar numbering) in a one-vessel reaction sequence of (a) conversion of
the lactones to their aldonic acid sodium salts, (b) cleavage of the r
esulting aldonates with sodium metaperiodate, and (c) acidification, f
ollowed by acetylation, to give the title compounds. The unsubstituted
tetrurono-1,4-lactones were inhibitory toward L1210 leukemia cells at
concentrations in the 10(-4) M range.