A REANALYSIS OF CARIES RATES IN A PREVENTIVE TRIAL USING POISSON REGRESSION-MODELS

Citation
Pp. Hujoel et al., A REANALYSIS OF CARIES RATES IN A PREVENTIVE TRIAL USING POISSON REGRESSION-MODELS, Journal of dental research, 73(2), 1994, pp. 573-579
Citations number
20
Categorie Soggetti
Dentistry,Oral Surgery & Medicine
Journal title
ISSN journal
00220345
Volume
73
Issue
2
Year of publication
1994
Pages
573 - 579
Database
ISI
SICI code
0022-0345(1994)73:2<573:AROCRI>2.0.ZU;2-Y
Abstract
The analysis of caries incidence in clinical trials has several challe nging features: (1) The distribution of the number of caries onsets pe r patient is skewed, with the majority of patients having few or no ca vities; (2) the number of surfaces at risk varies (i) over time and (i i) between patients, due to eruption and exfoliation patterns, dental diseases, and treatments; (3) surfaces within a patient differ in thei r caries susceptibility, and (4) caries onsets within a patient are co rrelated due to shared host factors. Recent statistical developments i n the area of correlated data analyses permit incorporation of some of these characteristics into the analyses. With Poisson regression mode ls, the expected number of caries onsets can be related to the number of surfaces at risk, the time they have been at risk, and surface- and subject-specific explanatory variables. The parameter estimated in th ese models is an epidemiological measure of disease occurrence: the di sease incidence rate (caries rate) or the rate of change from healthy (sound) to diseased (carious). Differences and ratios of these rates p rovide standard epidemiological measures of excess risk. To illustrate , Poisson regression models were used for exploratory analyses of the Ylivieska xylitol study.