CARBOXYLATION OF ACTIVE METHYLENE-COMPOUNDS USING ANILIDE, POTASSIUM CARBONATE, AND CARBON-DIOXIDE

Authors
CHIBA K TAGAYA H KARASU M ISHIZUKA M SUGO T
Citation
K. Chiba et al., CARBOXYLATION OF ACTIVE METHYLENE-COMPOUNDS USING ANILIDE, POTASSIUM CARBONATE, AND CARBON-DIOXIDE, Bulletin of the Chemical Society of Japan, 67(2), 1994, pp. 452-454
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
67
Issue
2
Year of publication
1994
Pages
452 - 454
Database
ISI
SICI code
0009-2673(1994)67:2<452:COAMUA>2.0.ZU;2-I
Abstract
Active methylene compounds were effectively carboxylated with carbon d ioxide in the presence of anilide (acetanilide or formanilide) and pot assium carbonate at 20-40-degrees-C for 0.5-10 h. In the carboxylation of fluorene, a high yield (48%) was obtained at 20-degrees-C for 4 h. The yield of carboxylic acid using 2,6-dimethylacetanilide was 8.9%, and smaller than 26.6% when using acetanilide at 20-degrees-C for 2 h, indicating the interference of a methyl group for the carboxylation.