We encountered a massive retroperitoneal haemorrhage due to perforatio
n of the external iliac vein by a drill tip passing through the antero
-superior quadrant of the acetabulum during cementless total hip arthr
oplasty. An anatomical study of the acetabulum was undertaken to deter
mine the safe zones for transacetabular screw fixation. Five cadavera
were studied to find the proper locations for screws using acetabular
quadrants. The postero-superior and postero-inferior acetabular quadra
nts have good bone stock and are safe for the transacetabular replacem
ent of screws. The antero-superior and inferior quadrants should be av
oided. Screws placed in these quadrants may damage the external iliac
artery and vein or the obturator vessels.