INFLUENCE OF GLYCEROL CONCENTRATION AND CARBOPOL MOLECULAR-WEIGHT ON SWELLING AND DRUG-RELEASE CHARACTERISTICS OF METOCLOPRAMIDE HYDROGELS

Authors
GONZALEZ NG KELLAWAY IW FUENTE HB IGEA SA CHARRO BD ESPINAR FJO MENDEZ JB
Citation
Ng. Gonzalez et al., INFLUENCE OF GLYCEROL CONCENTRATION AND CARBOPOL MOLECULAR-WEIGHT ON SWELLING AND DRUG-RELEASE CHARACTERISTICS OF METOCLOPRAMIDE HYDROGELS, International journal of pharmaceutics, 104(2), 1994, pp. 107-113
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
104
Issue
2
Year of publication
1994
Pages
107 - 113
Database
ISI
SICI code
0378-5173(1994)104:2<107:IOGCAC>2.0.ZU;2-O
Abstract
The formulation of glycerol-crosslinked Carbopol 907 and Carbopol 941 metoclopramide hydrogels for buccal administration were investigated. Infrared spectroscopy showed that crosslinking was the result of ester formation between Carbopol carboxyl groups and glycerol hydroxyl grou ps. The effects of Carbopol molecular weight and glycerol concentratio n on swelling and drug release characteristics were evaluated. In all glycerol-containing formulations drug dissolution efficiencies were lo w, and both dissolution efficiency and swelling rate decreased with in creasing glycerol concentration, confirming the very high crosslinking capacity of glycerol.