PREDICTION OF CARBAZOLE SOLUBILITY AND ITS DEPENDENCE UPON THE SOLVENT NATURE

On the basis of at most three parameters, the solubility of carbazole is predicted in 33 nonelectrolyte solvents by means of the general sol ubility equation derived from the thermodynamics of mobile order. Part icular attention is focussed on the influence of the formation of solu te-solvent stoechiometrical hydrogen bonds on the treatment of the non -specific dipole-dipole and dispersion interactions. Three classes of solvents can be distinguished according to their solubilizing potentia l towards carbazole: non-complexing solvents, complexing non-associate d solvents and complexing amphiphilic solvents. The analysis of the re lative importance of the different terms contributing to the solubilit y allows one to quantitatively understand its variation between the di fferent classes as well as within each class of solvents.