A COST-UTILITY ANALYSIS OF MISOPROSTOL PROPHYLAXIS FOR RHEUMATOID-ARTHRITIS PATIENTS RECEIVING NONSTEROIDAL ANTIINFLAMMATORY DRUGS

Objective. To determine the cost-utility of low-dose misoprostol proph ylaxis in rheumatoid arthritis (RA) patients treated with nonsteroidal antiinflammatory drugs (NSAIDs). Methods. Prospectively collected, po pulation-based data on 57 RA patients' preferences (obtained using the category scaling and time trade-off techniques), charge data from a c onsecutive, population-based cohort of 36 RA patients with NSAID-relat ed gastric ulcer, and literature-derived probability estimates were in corporated into a decision analysis model. Results. Probabilistic sens itivity analysis using 10,000 Monte Carlo simulations demonstrated tha t, on average, prophylaxis resulted in modest additional costs and no additional quality-of-life benefits. At best, the incremental cost per quality-adjusted life year gained was $9,333. At worst, prophylaxis r educed quality of life. Prophylaxis was cost-saving if the ulcer compl ication rate was >1.5%, or if the 3-month price of misoprostol was les s than or equal to$95.