FIRST TOTAL SYNTHESIS OF ASTECHROME - NOVEL HYDROXAMIC ACID WITH AN INDOLE-PYRAZINE SKELETON

Authors
JING H SHIMADA A MAEDA A ARAI Y GOTO M AOYAGI Y OHTA A
Citation
H. Jing et al., FIRST TOTAL SYNTHESIS OF ASTECHROME - NOVEL HYDROXAMIC ACID WITH AN INDOLE-PYRAZINE SKELETON, Chemical and Pharmaceutical Bulletin, 42(2), 1994, pp. 277-279
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
2
Year of publication
1994
Pages
277 - 279
Database
ISI
SICI code
0009-2363(1994)42:2<277:FTSOA->2.0.ZU;2-0
Abstract
Astechrome (1), isolated from Aspergillus terreus IFO 6123 and 8835, w as synthesized. Indolylmagnesium bromide (4) was coupled with a chloro methylpyrazine (5) to give 6-[7-(3-methyl-2-butenyl)indol-3-yl]methylp yrazine 1-oxide (6), which was converted to the Fe salt (9) of a hydro xamic acid derivative (8). Oxidation of 9 with Co(salen) afforded 1.