LANOSTEROL OLIGOSACCHARIDES FROM THE PLANTS OF THE SUBFAMILY SCILLOIDEAE AND THEIR ANTITUMOR-PROMOTER ACTIVITY

Phytochemical studies of the bulbs of Scilla peruviana, Eucomis bicolo r, Chionodoxa gigantea and C. luciliae gave respectively two new and t wo known, four new and two known, three known, and one new and five kn own lanosterol oligosaccharides. The structures of the new compounds w ere determined from spectroscopic data. A total of 19 lanosterols, inc luding previously isolated compounds, were examined for inhibitory act ivity on 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated P-32 in corporation into phospholipids of HeLa cells as the primary screening test to find new antirumor-promoter compounds.