SYNTHESIS AND LOCAL-ANESTHETIC ACTIVITY OF SOME THOXY-ANILIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENES

Authors
GADAD AK KUMAR H SHISHOO CJ KHAZI IM MAHAJANSHETTI CS
Citation
Ak. Gadad et al., SYNTHESIS AND LOCAL-ANESTHETIC ACTIVITY OF SOME THOXY-ANILIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 33(3), 1994, pp. 298-301
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
33
Issue
3
Year of publication
1994
Pages
298 - 301
Database
ISI
SICI code
0376-4699(1994)33:3<298:SALAOS>2.0.ZU;2-T
Abstract
Twenty new 2-substituted ino-3-carbetboxy/anilido-4,5,6,7-tetrahydrobe zo[b] thiophenes (4a-4t) have been synthesised with a view to studying the effect of structural modification of carticaine (B) on the local anaesthetic activity and evaluated by Sollman's method as well as Bulb ring and Wajda method using lignocaine hydrochloride as a standard. Al l the tested compounds show moderate to good activity and 4a has been found to be the most active drug comparable to the standard.