BOTH NEUROTOXIN-II FROM VENOM OF NAJA-NAJA OXIANA AND ITS ENDOGENEOUSANALOG INDUCE APOPTOSIS IN TUMOR-CELLS

Authors
STRIZHKOV BN BLISHCHENKO EY SATPAEV DK KARELIN AA
Citation
Bn. Strizhkov et al., BOTH NEUROTOXIN-II FROM VENOM OF NAJA-NAJA OXIANA AND ITS ENDOGENEOUSANALOG INDUCE APOPTOSIS IN TUMOR-CELLS, FEBS letters, 340(1-2), 1994, pp. 22-24
Citations number
16
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
340
Issue
1-2
Year of publication
1994
Pages
22 - 24
Database
ISI
SICI code
0014-5793(1994)340:1-2<22:BNFVON>2.0.ZU;2-7
Abstract
Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20-30 kD a proteins partially purified from pig brain (NTlm) cross-reacting wit h antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10(-6)-10(-8) M. Modification of Cys residues signif icantly reduced cytotoxicity of NT II. Both NT2 and NTlm induced apopt osis in L929 and K562 cells.