DELETION OF HIGHLY CONSERVED C-TERMINAL SEQUENCES IN THE KV1 K-TYPE CHARACTERISTICS( CHANNEL SUBFAMILY DOES NOT PREVENT EXPRESSION OF CURRENTS WITH WILD)

The C-terminal regions of Kv1 K+ channels show little conservation bet ween isoforms except for the last four C-terminal residues, (E/L)TDV, which are well conserved from Drosophila to man. Deletions of the 4, 1 6, and 57 C-terminal residues of the human Kv1.5 channel did not affec t whole cell current amplitude, midpoint of activation, degree of inac tivation, or activation kinetics following expression in mouse L-ceIls . Similar results were obtained with the rat Kv1.1 channel. Therefore, the conserved (E/L)TDV motif, and most of the C-terminal amino acids, are not required for Kv1 channel expression.