GENES FOR MEMBERS OF THE GATA-BINDING PROTEIN FAMILY (GATA-GT1 AND GATA-GT2) TOGETHER WITH H-ATPASE ARE SPECIFICALLY TRANSCRIBED IN GASTRICPARIETAL-CELLS(K+)

Authors
MUSHIAKE S ETANI Y SHIMADA S TOHYAMA M HASEBE M FUTAI M MAEDA M
Citation
S. Mushiake et al., GENES FOR MEMBERS OF THE GATA-BINDING PROTEIN FAMILY (GATA-GT1 AND GATA-GT2) TOGETHER WITH H-ATPASE ARE SPECIFICALLY TRANSCRIBED IN GASTRICPARIETAL-CELLS(K+), FEBS letters, 340(1-2), 1994, pp. 117-120
Citations number
15
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
340
Issue
1-2
Year of publication
1994
Pages
117 - 120
Database
ISI
SICI code
0014-5793(1994)340:1-2<117:GFMOTG>2.0.ZU;2-B
Abstract
mRNAs for novel DNA-binding proteins (GATA-GT1 and GATA-GT2) reconizin g the (G/C)PuPu(G/C)NGAT(A/T)PuPy sequence and H+/K+-ATPase (proton pu mp) alpha subunit were detected in parietal cells of the rat gastric b ody mucosa by in situ hybridization. These results suggest that GATA-G T1 and GATA-GT2 together with H+/K+-ATPase are transcribed specificall y in gastric parietal cells and that the two DNA-binding proteins may have important roles in cell specific gene regulation. Furthermore, we could detect parietal cells in different states of gene expression.