GONADECTOMY ABROGATES SEX-DIFFERENCES IN THE EFFECTIVENESS OF CHEMICAL CARCINOGENESIS IN MICE

Authors
SOMOGYI L JUKIC T BUKOVEC Z CULO F MARUSIC M
Citation
L. Somogyi et al., GONADECTOMY ABROGATES SEX-DIFFERENCES IN THE EFFECTIVENESS OF CHEMICAL CARCINOGENESIS IN MICE, Neoplasma, 41(1), 1994, pp. 17-19
Citations number
7
Categorie Soggetti
Oncology
Journal title
Neoplasma → ACNP
ISSN journal
00282685
Volume
41
Issue
1
Year of publication
1994
Pages
17 - 19
Database
ISI
SICI code
0028-2685(1994)41:1<17:GASITE>2.0.ZU;2-3
Abstract
Sham-gonadectomized and gonadectomized male and female mice were given methylcholanthrene s.c. to assess the influence of sex hormones on ca rcinogenesis. Gonadectomy decreased the concentration of the respectiv e sex hormone and increased the concentration of the opposite sex horm one. The results showed that androgens enhanced the effectiveness of c arcinogenesis, while estrogens had the opposite effect. Gonadectomy ef fectively abrogated the sex differences in tumor induction