EVALUATION OF PHTHALMUSTINE, A NEW ANTICANCER COMPOUND .1. EFFECT ON DALTONS ASCITIC LYMPHOMA IN MICE

The anticancer property of phthalmustine, a hitherto unknown compound containing N-mustard attached to the phthalimide ethyl chain was evalu ated using a murine tumor model. The results indicate that the compoun d was effective in significantly restraining tumor growth. This was ac companied by marked improvement in host survival. No toxic reactions w ere apparent reflected in skin and hair texture, body weight and behav ioral pattern (food and water intake and activity). Blood picture show ed a shift towards the normal following treatment. DNA synthesis in tu mor cells was found to be affected as revealed by radioactive thymidin e incorporation.