CASE-CONTROL STUDY OF RISK-FACTORS IN LARYNGEAL-CANCER

A case control study with 100 cases and 100 controls was conducted to test hypothetical risk factors in laryngeal cancer. McNemar's test hel ped to select 25 variables, 12 of which were indicated by the conditio nal logistic regression analysis as independently associated with lary ngeal cancer. The association was proved to be statistically significa nt In the case of seven risk factors; smoking more than 10 cigarettes per day (RR = 18.17; 95% CI 1.95-169.76), predominantly tinned food an d meat product diet (RR = 2.65; 95% CI 1.02-6.88), long term work expo sure to low temperatures and building, fabric and metal dust (RR = 4.5 3; 95% CI 1.80-11.37), extended stay in closed space filled with cigar ette smoke (RR = 2.67; 95% CI 1.08-6.60), recurrent hoarseness persist ing for more than 1 month (RR = 12.68; 95% CI 3.28-49.03), swollen nec k lymph nodes over a number of years (RR = 12.81; 95% CI 1.57-104.29). It was inferred that these seven tested variables could represent ris k factors in laryngeal cancer.