MAPPING OF THE GENES ENCODING MOUSE THROMBOXANE A(2) RECEPTOR AND PROSTAGLANDIN-E RECEPTOR SUBTYPES EP(2) AND EP(3)

Thromboxane A(2) (TXA(2)) and prostaglandin E(2) (PGE(2)) are two of t he most representative eicosanoids that are formed from arachidonic ac id. They produce a broad spectrum of biological effects mediated throu gh specific cell surface receptors. We have mapped genetic loci for TX A(2) receptor, Tbxa2r, and for PGE(2) receptor subtypes EP(2) and EP(3 ), Ptgerep2 and Ptgerep3, respectively, using restriction fragment len gth variants in interspecific backcross mice. None of the three loci c osegregated with each other. Tbxa2r mapped to Chr 10, Ptgerep2 mapped to the centromeric region of Chr 15, and Ptgerep3 mapped to the distal end of Chr 3. Possible human loci for these receptors are predicted b ased on the homology between mouse and human chromosomes. (C) 1994 Aca demic Press, Inc.