Optic disc correlations were evaluated in normal eyes by means of comp
uter-aided morphometry. Two hundred and thirty-five subjects (144 wome
n and 91 men) entered the study. One eye per patient was randomly chos
en for statistical analysis. Disc area (P < 0.05) and axial length (P
< 0.0001) were statistically different between sexes. There was a corr
elation between axial length and both disc area (r for females = 0.55,
P < 0.00001; r for males = 0.35, P < 0.0007) and refraction (r for fe
males = 0.40, P < 0.00001; r for males = 0.50, P < 0.00001). The main
findings of this investigation were that disc area is greater in male
than in female eyes (thus clinically confirming the Ishi's and Quigley
's previous observations of autopsy eyes) on the basis of axial length
difference between the two sexes, and that disc size correlated with
axial length. Disagreements in disc measurements reported in previous
studies may be caused by differences in the male/female ratios of thei
r samples.