THE MODE OF ACTION AND THE MECHANISM OF RESISTANCE TO ANTIMALARIAL-DRUGS

Citation
Sj. Foote et Af. Cowman, THE MODE OF ACTION AND THE MECHANISM OF RESISTANCE TO ANTIMALARIAL-DRUGS, Acta Tropica, 56(2-3), 1994, pp. 157-171
Citations number
95
Categorie Soggetti
Biology,"Tropical Medicine",Parasitiology
Journal title
ISSN journal
0001706X
Volume
56
Issue
2-3
Year of publication
1994
Pages
157 - 171
Database
ISI
SICI code
0001-706X(1994)56:2-3<157:TMOAAT>2.0.ZU;2-J
Abstract
The mechanism of action of the antifolate and quinoline antinialarials has been investigated over the last few decades, and recent advances should aid the development of new drugs to combat the increasingly ref ractile parasite. The molecular description of resistance to the antif olates has been well characterised and is due to structural changes in the target enzymes, but the factors involved in the parasite's abilit y to circumvent the action of the quinoline antimalarials have yet to be fully elucidated. This review discusses the mode of action of these drugs and the means used by the parasite to defeat our therapeutic in genuity.