Dj. Chetty et Cm. Dangor, THE DEVELOPMENT OF AN ORAL CONTROLLED-RELEASE PELLETS FORMULATION OF DIETHYLPROPION HYDROCHLORIDE, Drug development and industrial pharmacy, 20(6), 1994, pp. 993-1005
In the present study, controlled release pellets of the anorexigenic,
diethylpropion hydrochloride were formulated. Selected polymeric film
coatings were applied to the drug-loaded non pareils and their effect
on in vitro drug release from the multiple-units dosage form was exami
ned. It was found that a combination of Eudragit(R) RS, polyethylene g
lycol 200 and magnesium stearate produced a stable film coat that cont
rolled drug release as desired. Dissolution data demonstrated that thi
s formulation displayed predictable and reproducible drug release char
acteristics.