IMMUNOCYTOCHEMICAL IDENTIFICATION OF ANDROGEN RECEPTOR IN MOUSE OSTEOCLAST-LIKE MULTINUCLEATED CELLS

Authors
MIZUNO Y HOSOI T INOUE S IKEGAMI A KANEKI M AKEDO Y NAKAMURA T OUCHI Y CHANG C ORIMO H
Citation
Y. Mizuno et al., IMMUNOCYTOCHEMICAL IDENTIFICATION OF ANDROGEN RECEPTOR IN MOUSE OSTEOCLAST-LIKE MULTINUCLEATED CELLS, Calcified tissue international, 54(4), 1994, pp. 325-326
Citations number
18
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Calcified tissue international → ACNP
ISSN journal
0171967X
Volume
54
Issue
4
Year of publication
1994
Pages
325 - 326
Database
ISI
SICI code
0171-967X(1994)54:4<325:IIOARI>2.0.ZU;2-5
Abstract
Expression of androgen receptor (AR) in mouse osteoclast-like multi-nu cleated cells (OCs) was examined with immunocytochemical techniques. M urine OCs were obtained by co-culturing mouse osteoblastic cells and b one marrow cells. Three preparations of polyclonal anti-AR antibody wh ich were raised in rabbit against different parts of the human AR were employed for the experiments. Specific staining for AR was demonstrat ed in the nuclei and the perinuclear area of mouse OCs. This is the fi rst report demonstrating the presence of AR in osteoclast-like cells.