INFLUENCE OF UPRIGHT ACTIVITY ON PLASMA-RENIN ACTIVITY AND ALDOSTERONE CONCENTRATION IN CHILDREN

Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured in 156 healthy infants and children under basal conditi ons of normal diet and recumbency. PRA and PAC were also evaluated dur ing and after stimulation of the renin-angiotension-aldosterone system by postural change. Basal values of PRA significantly declined with i ncreasing age. Postural change by standing up resulted in an increase of PRA and PAC in all age groups. The increment of PRA but not of PAC was greater in older than in younger children. Neither the basal nor t he stimulated levels of PRA and PAC were influenced by sex, body weigh t, body surface area, serum sodium, serum potassium, creatinine, and 2 4-h urine secretion of sodium and potassium. Both PRA and PAC returned to the basal levels within 60 min after resuming recumbent posture.