THE SYMPTOMATOLOGY OF PROGESTOGEN INTOLERANCE

It is common for women receiving oestrogen replacement therapy to expe rience adverse symptoms whilst taking cyclical progestogen. This study highlights the similarity of these symptoms to those experienced in p re-menstrual syndrome and confirms that the Moos Menstrual Distress Qu estionnaire is an appropriate tool for future research. The data also indicate that progestogens vary in the type of symptoms they cause. No rethisterone is more likely to cause symptoms from the Moos pain sympt om cluster than either medroxyprogesterone or dydrogesterone, but is l ess likely to cause negative affect symptom duster symptoms. The relat ive levels of oestrogen and progestogen may influence the severity of progestogenic symptoms.