LOCALIZATION OF A HUMAN RECEPTOR TYROSINE KINASE (ETK1) TO CHROMOSOMEREGION 3P11.2

We have recently described a human receptor tyrosine kinase (hek) that is expressed by some pre-B and thymic T cell lines, but is not detect able on normal adult human tissues. Gene cloning studies established t hat hek is a new member of the EPH family of receptor tyrosine kinases . The expression of hek may normally be developmentally regulated and inappropriate expression may contribute to oncogenesis. In the present study, we have used Southern blot analysis of somatic cell hybrids an d fluorescence in situ hybridization to localize the hek gene to human chromosome region 3p11.2. Karyotype analysis of the cell lines that o verexpress hek showed no cytogenetically visible abnormality involving the hek locus. (C) 1994 Academic Press, Inc.