ZINC AND MAGNESIUM IN LIVER-CIRRHOSIS

The Authors determined zinc (Zn) and magnesium (Mg) in the plasma, uri ne, erythrocytes (RBCs), mono- and polymorphonuclear cells (MNCs and P MNs) of patients with overt alcoholic and nonalcoholic liver cirrhosis . In order to obtain a clearer clinical picture, biochemical and nutri tional parameters (retinol, tocopherol, six different carotenoids, cre atinine-height index and tricipital skinfold), as well as markers of p ortal hypertension (spleno-portal size and platelet count) were also e valuated. The plasma levels of Zn and Mg were found to be reduced, as were the urine levels of Mg. Urine Zn, on the other hand, was higher t han normal. Plasma Zn correlated inversely, and urine Zn directly, wit h the severity of the disease, rather than with alcohol consumption or treatment with diuretics. Protein metabolism impairment would appear to affect the plasma transport of Zn rather than its overall availabil ity in the organism; the opposite was found in the case of Mg, the ava ilability of which appeared to be reduced. Determination of the two el ements in RBCs, MNCs and PMNs suggested that a true nutritional defici t cannot be demonstrated. MNCs, rather than RBCs or PMNs seem better t o reflect tissue status of trace elements.