SYNTHESIS AND BIOLOGICAL PROPERTIES OF NEW NALTREXONE-PEPTIDE HYBRIDS

Authors
LIPKOWSKI AW PASTERNAK GW MISTEREK K GUMULKA SW PACHOCKA M
Citation
Aw. Lipkowski et al., SYNTHESIS AND BIOLOGICAL PROPERTIES OF NEW NALTREXONE-PEPTIDE HYBRIDS, Regulatory peptides, 1994, pp. 190000127-190000128
Citations number
3
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Regulatory peptides → ACNP
ISSN journal
01670115
Year of publication
1994
Supplement
1
Pages
190000127 - 190000128
Database
ISI
SICI code
0167-0115(1994):<190000127:SABPON>2.0.ZU;2-V
Abstract
Hybridization of benzomorphan alkaloids with opioid peptide ''addresse s'' is one of the successful method of modulation of receptor selectiv ity and affinity of opioid ligands. In this paper we present biologica l properties of two new compounds, hybridized naltrexone with Leu-D-Ph e-NHNH2 or BrAc-Leu-D-Phe-NHNH2. These semicarbazides express signific ant increase in affinity to delta receptors.