STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANALOGS OF HIGHLY POTENT OPIOID PEPTIDE BIPHALIN

Authors
MISICKA A LIPKOWSKI AW HORVATH R DAVIS P PORRECA F YAMAMURA HI HRUBY VJ
Citation
A. Misicka et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANALOGS OF HIGHLY POTENT OPIOID PEPTIDE BIPHALIN, Regulatory peptides, 1994, pp. 190000131-190000132
Citations number
3
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Regulatory peptides → ACNP
ISSN journal
01670115
Year of publication
1994
Supplement
1
Pages
190000131 - 190000132
Database
ISI
SICI code
0167-0115(1994):<190000131:SOAOHP>2.0.ZU;2-Y
Abstract
For SAR study of biphalin [(Tyr-D-Ala-Gly-PheNH-)(2)] we have synthesi zed several analogues with modifications of amino acid residues in pos ition 3 and 4. The introduction of halogenated phenylalanine residues in position 4 increases affinity to delta receptors. Introducing basic aromatic amino acid residues in position 4 resulted in decrease in af finity to mu receptors, but preserve affinity to delta receptors.