INTERACTION BETWEEN MORPHINE AND OPIOID-PEPTIDES AFTER SC ADMINISTRATION

Authors
MASZCZYNSKA I MIKASZEWSKA M KOSSON D CARR DB SZYFELBEIN SK LIPKOWSKI AW
Citation
I. Maszczynska et al., INTERACTION BETWEEN MORPHINE AND OPIOID-PEPTIDES AFTER SC ADMINISTRATION, Regulatory peptides, 1994, pp. 190000243-190000244
Citations number
1
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Regulatory peptides → ACNP
ISSN journal
01670115
Year of publication
1994
Supplement
1
Pages
190000243 - 190000244
Database
ISI
SICI code
0167-0115(1994):<190000243:IBMAOA>2.0.ZU;2-Y
Abstract
It is possible that peripheral analgesic targets may enhance central a nalgesia. We present our preliminary results of selected opioid peptid es on morphine (MOR) analgesia. Coinjection of dermorphin with MOR res ulted in antinociceptive synergy, whereas morphiceptin coinjected with MOR yielded antinociceptive activity lower than MOR alone. At lower d oses of MOR, DADLE strongly potentiates analgesia, but at higher doses of MOR, DADLE inhibits the antinociceptive effect of MOR.