PERIODIC MATERNAL DEPRIVATION-INDUCED POTENTIATION OF THE NEGATIVE FEEDBACK SENSITIVITY TO GLUCOCORTICOIDS TO INHIBIT STRESS-INDUCED ADRENOCORTICAL-RESPONSE PERSISTS THROUGHOUT THE ANIMALS LIFE-SPAN

Authors
MUNEOKA K MIKUNI M OGAWA T KITERA K TAKAHASHI K
Citation
K. Muneoka et al., PERIODIC MATERNAL DEPRIVATION-INDUCED POTENTIATION OF THE NEGATIVE FEEDBACK SENSITIVITY TO GLUCOCORTICOIDS TO INHIBIT STRESS-INDUCED ADRENOCORTICAL-RESPONSE PERSISTS THROUGHOUT THE ANIMALS LIFE-SPAN, Neuroscience letters, 168(1-2), 1994, pp. 89-92
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
168
Issue
1-2
Year of publication
1994
Pages
89 - 92
Database
ISI
SICI code
0304-3940(1994)168:1-2<89:PMDPOT>2.0.ZU;2-4
Abstract
In this study, it was clearly demonstrated that the enhanced negative feedback sensitivity to glucocorticoids to inhibit stress-induced adre nocortical response, which was produced by periodic maternal deprivati on (PMD) treatment for the first 3 weeks of life, did persist in rats tested at 66 and 92 weeks of life, suggesting that some stressful expe rience during early life permanently alters the adrenocortical respons e to stressful stimuli. This effect of PMD was not accompanied by an i ncreased density of glucocorticoid receptor binding sites in the hippo campus from 93-week-old rats.