AMYLOID PRECURSOR PROTEIN MUTATION CAUSES ALZHEIMERS-DISEASE IN A SWEDISH FAMILY

Since the report of a double mutation at codons 670 and 671 of the amy loid precursor protein (APP) gene identified in two Swedish families w ith clinically diagnosed Alzheimer's disease (AD), a carrier with deme ntia has died. Neuropathology confirmed the clinical diagnosis of AD. Genealogical investigations have confirmed that the two families are r elated to common founders. Two-point linkage analysis of the mutation versus the disease in the revised pedigree now gives a lod score of 7. 62.