PERINATAL RESULTS OF HEMODYNAMIC AND CONSERVATIVE TEMPORIZING TREATMENT IN SEVERE PREECLAMPSIA

Objective: To evaluate maternal and perinatal outcome of hemodynamic t emporizing management in severe pre-eclampsia. Design: Study group of 57 pre-eclamptic women, gestational age 35 weeks or less, treated with plasma volume expansion and vasodilatation under invasive hemodynamic monitoring, retrospectively matched with a control group treated in a nother center without volume expansion and invasive monitoring. Result s: In both groups pregnancy was prolonged with 10-11 days. Maternal mo rbidity was low in both groups. No complications of hemodynamic monito ring were observed. Perinatal mortality was not significantly differen t between the study group (7.1%) and the control group (14.3%). SGA-in fants were significantly less frequent in the study group (9%) than in controls (33%). Conclusion: Temporizing treatment of patients with ea rly severe pre-eclampsia, with or without plasma volume expansion and invasive hemodynamic monitoring, may reduce neonatal mortality and mor bidity. The difference in birthweight between study group and control group may be an effect of the therapy or may be caused by selection bi as. The perinatal outcome in the study group suggests that there may b e a subgroup of patients who might benefit from hemodynamic treatment.