INCREASED FREQUENCY OF THE S ALLELE OF THE L-MYC ONCOGENE IN NON-HODGKINS-LYMPHOMA

We studied 100 patients with non-Hodgkin's lymphoma, 44 patients with Hodgkin's disease and 100 controls for the prevalence of the EcoRI res triction fragment polymorphism of the L-myc oncogene. No difference in the frequency of the three genotypes (LL, LS, SS) was found between t he patient and control groups. However, the S allele was found to occu r more frequently in the non-Hodgkin's lymphoma patients (chi2 = 4.57, P = 0.032). These data confirm an earlier report and suggest that the presence of the S allele is associated with susceptibility to non-Hod gkin's lymphoma.